isocitrate dehydrogenase - перевод на арабский
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isocitrate dehydrogenase - перевод на арабский

CLASS OF ENZYMES
Isocitrate dehydrogenase (NADP+); Idh1; EC 1.1.1.42; Isocitrate:NADP+ oxidoreductase (decarboxylating)
  •  s2cid = 36093146 }}</ref>
  •  doi = 10.1128/JB.01799-07 }}</ref>
  • thumb
  • Decarboxylation of oxalosuccinate.<ref name="nfr154197/32"/>
  • Oxidoreductase step where NAD<sup>+</sup> is used to accept a hydride.<ref name="nfr154197/32"/>
  • Saturation of the alpha-beta unsaturated double bond.<ref name="nfr154197/32"/>
  • Porcine Mitochondrial NADP<sup>+</sup>-dependent Isocitrate Dehydrogenase Complexed with Mn<sup>2+</sup> and Isocitrate.<ref name="hl67774"/>
  • Porcine IDH complex, Arg AA stabilizing isocitrate in the active site. residues Arg110, Arg133, and Arg101 are the three main stabilizing amino acids. They help to hold isocitrate in the active site and in the right orientation for isocitrate dehydrogenase to take place.<ref name="hl67774"/>
  • Porcine Enzyme complex; Active site isocitrate and adjacent A.A.<ref name="hl67774"/>
  •  doi-access = free }}</ref>
  • One active site on the Porcine NADP<sup>+</sup> dependent enzyme (green).<ref name="hl67774"/> Porcine enzyme is a homodimer and has another active site on the other side.

isocitrate dehydrogenase         
‎ نازِعَةُ هيدرُوجين الإيزوسيترات‎
lactic dehydrogenase         
  • 400px
  • Arrow pushing mechanism for the reaction catalyzed by lactate dehydrogenase
  • Reaction catalyzed by lactate dehydrogenase
‎ نازِعَةُ هيدروجينِ اللَّاكْتات‎
lactate dehydrogenase         
  • 400px
  • Arrow pushing mechanism for the reaction catalyzed by lactate dehydrogenase
  • Reaction catalyzed by lactate dehydrogenase
‎ نازِعَةُ هيدروجينِ اللَّاكْتات‎

Определение

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Википедия

Isocitrate dehydrogenase

Isocitrate dehydrogenase (IDH) (EC 1.1.1.42) and (EC 1.1.1.41) is an enzyme that catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO2. This is a two-step process, which involves oxidation of isocitrate (a secondary alcohol) to oxalosuccinate (a ketone), followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate. In humans, IDH exists in three isoforms: IDH3 catalyzes the third step of the citric acid cycle while converting NAD+ to NADH in the mitochondria. The isoforms IDH1 and IDH2 catalyze the same reaction outside the context of the citric acid cycle and use NADP+ as a cofactor instead of NAD+. They localize to the cytosol as well as the mitochondrion and peroxisome.